The City of Louisville Diarrhea (CLOUD) study was created in partnership with Pfizer to determine the diarrhea burden in adults in the United States attributable to Clostridioides difficile infection (CDI). Led by Dr. Julio Ramirez, Chief of Infectious Diseases at the University of Louisville, the CLOUD study is an ongoing, international study designed to generate consistent and comparable population-based incidence in the inpatient setting.
The CDI burden in the United States is high, prompting the Centers for Disease Control and Prevention (CDC) to classify CDI as an urgent public health threat that requires immediate and aggressive action. According to hospital-based national surveillance of hospital-acquired infections conducted by CDC, the CDI incidence in United States hospitals nearly doubled from 2001 to 2010. Unfortunately, the CDI disease burden in the United States has remained largely unchanged in recent years. The proportion of community-onset CDI cases increased to 44% in 2015, continuing the trend of rising community-onset CDI.
This multi-hospital, active surveillance study will measure the population-based incidence of hospitalized CDI for adults ≥50 years of age in Louisville, Kentucky. Study findings will inform future treatment options that will reduce the diarrhea burden attributable to Clostridioides difficile infection (CDI) in the United States.